The subjects were asked to attend a clinic after an overnight fast for further investigations.
A social worker performed home visits and recorded each subject’s occupation and level of education, physical activity, and alcohol and tobacco consumption. More than 30 percent of the cohort (2414 subjects) was lost to follow-up between the end of phase 1 and the beginning of phase 2, a time when unauthorized housing was demolished in South Delhi.įrom August 1998 to August 2002, we located 2584 (31.6 percent) of the initial cohort. There were several phases in this cohort study ( Fig. Trained personnel recorded the weight and the length or height of the babies within 72 hours after birth at the ages of 3, 6, 9, and 12 months (☗ days) and at 6-month intervals (☑5 days) thereafter. There were 9169 pregnancies, resulting in 8181 live births (8030 singletons and 151 twins), 202 stillbirths, and 867 abortions. Women who became pregnant were seen by a health visitor every 2 months (☓ days) initially and on alternate days from the 37th week of gestation. Among a population of 119,799, there were 20,755 married women of reproductive age who were assessed every other month (☓ days) in order to record menstrual dates. 10 All families living there between December 1, 1969, and November 30, 1972, were identified. This study of pregnancy outcomes and childhood growth was begun in 1969 in a defined area of 12 km 2 in South Delhi, India. We examined the incidence of impaired glucose tolerance and type 2 diabetes in a population study of young adults raised in the era of nutritional transition in India whose growth has been recorded prospectively since birth. Thus, longitudinal studies are required to determine the age at which preventive interventions should be initiated.
4- 8 It is unclear whether the crucial phase of postnatal weight gain is in infancy, childhood, adolescence, or adulthood. Studies have consistently shown high rates of this disease in people who were born small but became overweight as adults.
Type 2 diabetes may originate from events initiated during fetal development and in patterns of childhood weight gain. 1- 3 This epidemic has been attributed to what has been called “nutritional transition” (increased availability of food, reduced physical activity, and increases in obesity) - changes that are most marked in urban populations. The prevalence of type 2 diabetes mellitus is increasing rapidly in developing countries such as India.
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